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Friday, October 9, 2020 | History

4 edition of Synthesis and biological activity of conformationally constrained nucleosides and nucleotides found in the catalog.

Synthesis and biological activity of conformationally constrained nucleosides and nucleotides

Girolamo Tusa

Synthesis and biological activity of conformationally constrained nucleosides and nucleotides

by Girolamo Tusa

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  • 4 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1998.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL18727623M
ISBN 100612340325
OCLC/WorldCa46579549

The AS ODNs with ‘North’ conformationally constrained nucleotides have attracted considerable attention because of their ability to drive the ODN strand of the ODN–RNA hybrid duplex to an RNA type orientation, thereby increasing target affinity (3,25). Such molecules can be . 7 Synthesis of C-Nucleosides Omar Boutureira, M. Isabel Matheu, Yolanda D´ıaz, and Sergio Castill´on 8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance Maurice Okello and Vasu Nair 9 Synthesis of Conformationally Constrained Nucleoside Analogues

Here, he works on the synthesis of conformationally locked methanocarba nucleos(t)ides targeting GPCRs and kinases. Kiran received his PhD () under the guidance of Prof. Serge Van Calenbergh, for the thesis Synthesis and Biological Evaluation of 4′-Hydroxymethyl Deleted, Transposed and Modified Nucleosides at Ghent University, Belgium. He. Choi Y, Moon HR, Yoshimura V, Marquez VE. Recent advances in the synthesis of conformationally locked nucleosides and their success in probing the critical question of conformational preferences by their biological targets. Nucleosides Nucleotides Nucleic Acids. ; –

A new synthesis of 5′-deoxy-8,5′-cyclo-adenosine and -inosine: conformationally-fixed purine nucleosides (nucleosides and nucleotides XVI) January Nucleic Acids Research 3(12) Nucleosides, Nucleotides & Nucleic Acids List of Issues Vol Issue 9 Impact Factor. Nucleosides, Nucleotides & Nucleic Acids. Impact Factor. Synthesis of N-substituted morpholine nucleoside derivatives. Mikhail D. Nekrasov, Evgeny R. Lukyanenko & Alexander V. Kurkin.


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Synthesis and biological activity of conformationally constrained nucleosides and nucleotides by Girolamo Tusa Download PDF EPUB FB2

Spthesis and Biologicai Activity of Conformationaliy Constrained NucIeosides and Nuc1eotides Degree of Master of Science, by Girolamo Tusa Graduate Department of Chemistry, University of Toronto This thesis outhes the synthesis of a variety of confonnationally constrained nucleosides and nucleotide analogues.

The conformationally 'locked" analogues closelyAuthor: Girolamo Tusa. Synthesis of two types of bicyclic conformationally constrained nucleosides, North-East locked 1',2'-azetidine and North locked 2',4'-aza-ENA, is described.

Study of the molecular structures and dynamics of bicyclic nucleosides showed that depending upon the type of fused system they fall into two distinct categories with their respective. Stereoselective Synthesis of Conformationally Constrained 2′-Deoxy-4′-thia β-Anomeric Spirocyclic Nucleosides Featuring Either Hydroxyl Configuration at C5′.

ChemInform36 (32) DOI: /chinCited by: Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional.

The structure−activity relationships of adenosine-3‘,5‘-bisphosphates as P2Y1 receptor antagonists have been explored, revealing the potency-enhancing effects of the N6-methyl group and the ability to substitute the ribose moiety (Nandanan et al. Med. Chem.42, −). We have introduced constrained carbocyclic rings (to explore the role of sugar puckering), non-glycosyl Cited by: 7 Synthesis of C-Nucleosides Omar Boutureira, M.

Isabel Matheu, Yolanda D´ýaz, and Sergio Castill´on. 8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance Maurice Okello and Vasu Nair.

9 Synthesis of Conformationally Constrained Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues.

The book also includes experimental procedures for key reactions related to the synthesis. Here, he works on the synthesis of conformationally locked methanocarba nucleos(t)ides targeting GPCRs and kinases. Kiran received his PhD () under the guidance of Prof.

Serge Van Calenbergh, for the thesis Synthesis and Biological Evaluation of 4 ʹ -Hydroxymethyl Deleted, Transposed and Modified Nucleosides at Ghent University, Belgium. Abstract A set of pyrimidine nucleosides fused with a 4′‐C,3′‐O‐propylene bridge was successfully synthesised in 12 steps from 1,6‐di‐O‐isopropylidene‐α‐D‐glucofuranose, an inexpensive starting.

Recent Advances in the Synthesis of Conformationally Locked Nucleosides and Their Success in Probing the Critical Question of Conformational Preferences by Their Biological Targets. Nucleosides, Nucleotides and Nucleic Acids22 (),   Here, he works on the synthesis of conformationally locked methanocarba nucleos(t)ides targeting GPCRs and kinases.

Kiran received his PhD () under the guidance of Prof. Serge Van Calenbergh, for the thesis Synthesis and Biological Evaluation of 4ʹ-Hydroxymethyl Deleted, Transposed and Modified Nucleosides at Ghent University, Belgium. Synthesis of nucleosides involves the coupling of a nucleophilic, heterocyclic base with an electrophilic sugar.

The silyl-Hilbert-Johnson (or Vorbrüggen) reaction, which employs silylated heterocyclic bases and electrophilic sugar derivatives in the presence of a Lewis acid, is the most common method for forming nucleosides in this manner.

Conformational-analysis of sugar ring in nucleosides and nucleotides – improved method for interpretation of proton magnetic-resonance coupling-constants.

Conformationally locked carbocyclic nucleosides built on a bicyclo[]hexane template with a fixed southern conformation. synthesis and antiviral activity. Synthesis of north-5'-methylbicyclo[]hexyl adenine and hypoxanthine nucleosides with an ethenyl group at C3' position was successfully achieved by a highly facile method.

Recent Advances in the Synthesis of Conformationally Locked Nucleosides and Their Success in Probing the Critical Question of Conformational Preferences by Their Biological Targets. Nucleosides, Nucleotides and Nucleic Acids22 (), DOI: /NCN Synthesis, Crystal Structure, and in Vitro Biological Evaluation of C-6 Pyrimidine Derivatives: New Lead Structures for Monitoring Gene Expression in Vivo.

Nucleosides, Nucleotides and Nucleic Acids30 (4), DOI: /   Contributors ix Foreword xiii Preface xv 1 Biocatalytic Methodologies for Selective Modified Nucleosides 1 Miguel Ferrero, Susana Fern'andez, and Vicente Gotor 2 Nucleosides Modified at the Base Moiety 49 O.

Sari, V. Roy, and L. Agrofoglio 3 Chemical Synthesis of Acyclic Nucleosides Hai-Ming Guo, Shan Wu, Hong-Ying Niu, Ge Song, and Gui-Rong Qu 4. Yoshihiro Moai, Hidekazu Hiroaki, Saoshi Obika, Tetsuya Kodama, Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base, Nucleosides, Nucleotides and Nucleic Acids, /, (), ().

Maqbool A. Siddiqui, Harry Ford, Clifford George, Victor E. Marquez, Synthesis, Conformational Analysis, and Biological Activity of a Rigid Carbocyclic Analogue of 2′-Deoxy Aristeromycin Built on a Bicyclo[]hexane Template, Nucleosides and Nucleotides, /, 15,(), ().

A new and efficient synthesis of the important carbobicyclic template 14a, a useful intermediate for the synthesis of (N)MCdAdo (8) and other conformationally restricted nucleosides, is also reported.

In general, the ribose rings of nucleosides and nucleotides may adopt a range of conformations; this has been described as a pseudorotational cycle.

1 The Northern ((N), 2′-exo, 3′-endo) and Southern ((S), 2′-endo, 3′-exo) conformations are the most relevant to the biological activities observed for nucleosides and nucleotides in association with DNA, RNA, and various enzymes.

1–6.Analysis, and Biological Activity of a Rigid Carbocyclic Analogue of 2'-Deoxy Aristeromycin Built on a Bicyclo[]hexane Template',Nucleosides, Nucleotides and Nucleic Acids, —   A new class of conformationally locked nucleosides, restricted by a difluoromethylene bridge between the C3′ C4′ bond was reported in by Robins and coworkers.

28 Marquez and coworkers reported the synthesis of a racemic adenyl analog of the Okabe nucleoside in 29 as a novel variant in which the hydroxymethyl group was located at C3′ thereby creating a quaternary .